ikba nfkb | IκBα

Keyword	CPC	PCC	Volume	Score	Length of keyword
ikba nfkb	0.61	0.4	423	85	9
ikba	1.48	0.6	5932	33	4
nfkb	1.43	0.9	5652	85	4

Keyword	CPC	PCC	Volume	Score
ikba nfkb	1.15	1	1698	61

Search Results related to ikba nfkb on Search Engine

IκBα - Wikipedia
wikipedia.org

https://en.wikipedia.org/wiki/I%CE%BAB%CE%B1

IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha) is one member of a family of cellular proteins that function to inhibit the NF-κB transcription factor.IκBα inhibits NF-κB by masking the nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm.

DA: 31 PA: 62 MOZ Rank: 59

I B kinases: key regulators of the NF-kB pathway
cell.com

https://www.cell.com/trends/biochemical-sciences/pdf/S0968-0004(03)00310-4.pdf

[1,3,4]. Thus, increased phosphorylation of IkBa by the IkB kinases results in the ubiquitination and proteasomal degradation of IkBa. This process, which is a key step in the regulation of the NF-kB pathway, liberates the NF-kB proteins from IkBa, leading to their nuclear translocation and binding to kB promoter elements to result in

DA: 14 PA: 21 MOZ Rank: 60

NF-kB Transcription Factors | Boston University
bu.edu

http://www.bu.edu/nf-kb/

Newly-synthesized IkBa can enter the nucleus, remove NF-kB from DNA, and export the complex back to the cytoplasm to restore the original latent state. Thus, the activation of the NF-kB pathway is generally a transient process, lasting from 30-60 minutes in most cells.

DA: 17 PA: 84 MOZ Rank: 42

NFKBIA Gene - GeneCards | IKBA Protein | IKBA Antibody
genecards.org

https://www.genecards.org/cgi-bin/carddisp.pl?gene=NFKBIA

NFKBIA (NFKB Inhibitor Alpha) is a Protein Coding gene. Diseases associated with NFKBIA include Ectodermal Dysplasia And Immunodeficiency 2 and Hypohidrotic Ectodermal Dysplasia With Immunodeficiency.Among its related pathways are ATM Pathway and GDNF-Family Ligands and Receptor Interactions.Gene Ontology (GO) annotations related to this gene include identical protein binding and transcription ...

DA: 34 PA: 12 MOZ Rank: 69

Phosphorylation of NF-kB and IkB proteins: implications in ...
uliege.be

https://orbi.uliege.be/bitstream/2268/1280/1/21.%20Review%20phosphorylation%20NF-kB%20TIBS.pdf

phosphorylation of IkBa at speciﬁc residues, ubiquitination through binding of ubiquitin proteins and degradation of this inhibitory molecule via the proteasome pathway. Then, the heterodimer p50–p65 is released and migrates to the nucleus where it binds to speciﬁc kB sites and activates a variety of NF-kB target genes, including IL-8, IL-6,

DA: 37 PA: 35 MOZ Rank: 37

Nuclear Export of the NF-κB Inhibitor IκBα Is Required for ...
ucla.edu

https://www.signalingsystems.ucla.edu/pubs/Wuerzberger.pdf

Immunity Article Nuclear Export of the NF-kB Inhibitor IkBa Is Required for Proper B Cell and Secondary Lymphoid Tissue Formation Shelly M. Wuerzberger-Davis,1,8 Yuhong Chen,2,8 David T. Yang,3 Jeffrey D. Kearns,4 Paul W. Bates,1,9 Candace Lynch,4 Nicholas C. Ladell,1 Mei Yu,2,5 Andrew Podd, 2,6 Hu Zeng, 5 Tony T. Huang,7 Renren Wen, Alexander Hoffmann,4 Demin Wang,2 ,5 6 *and Shigeki Miyamoto1

DA: 30 PA: 70 MOZ Rank: 33

IKKa and IKKb Each Function to Regulate NF-kB Activation ...
semanticscholar.org

https://pdfs.semanticscholar.org/09cd/6c802d1e9d523c0136a02c7f751041060c35.pdf

phospho-specific NF-kB p65 (Ser-536) and IkBa (Ser 32/36) were obtained from Cell Signaling. Antibodies to b-tubulin and to IkBa were obtained from Santa Cruz. Antibodies to IKKa and IKKb were obtained from Upstate Biotechnology Inc. RhTNF-a (Promega) was used at a final concentration of 10 ng/ml.

DA: 75 PA: 22 MOZ Rank: 78

Anatomy of a negative feedback loop: the case of IkB
ucla.edu

http://www.signalingsystems.ucla.edu/pubs/Fagerlund2015.pdf

dynamic control of NFkB even though IkBbexpression was under NFkB control similar to IkBa(figure 1c; electronic sup-plementary material, figure S1A). However, when another known IkB negative feedback regulator, IkBe[17], was linked to this promoter, NFkB activity did show post-induction repression (electronic supplementary material, figure S1B).

DA: 27 PA: 21 MOZ Rank: 96

What methods can be used to detect NF-kB activation?
researchgate.net

https://www.researchgate.net/post/What-methods-can-be-used-to-detect-NF-kB-activation

I'm not familiar with NFKB signaling, but it seems that it might be relevant for my current project. I recently observed that 24h LPS treatment increased both p-IKBa and total IKBa.

DA: 36 PA: 9 MOZ Rank: 48