Keyword Analysis & Research: menthofuran


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What is menthofuran in pennyroyal?

Menthofuran is an organic compound found in a variety of essential oils including that of pennyroyal ( Mentha pulegium ). It is highly toxic and believed to be the primary toxin in pennyroyal responsible for its potentially fatal effects.

What is menthofuran in peppermint oil?

Menthofuran occurs as the (+) isomer, in peppermint essential oils. It is a colorless liquid with a minty odor. 4,5,6,7-Tetrahydro-3,6-dimethylbenzofuran has an odor very similar to that of menthol. Reported found in peppermint oil, corn mint oil, spearmint oil, Scotch spearmint oil, pennyroyal oil and other Mentha oils and buchu oil.

Is menthofuran toxic to humans?

It is highly toxic and believed to be the primary toxin in pennyroyal responsible for its potentially fatal effects. After ingestion of menthofuran, it is metabolically activated to chemically reactive intermediates that are hepatotoxic. Menthofuran is produced biosynthetically from pulegone by the enzyme menthofuran synthase .

What is the mechanism of action of menthofuran?

Menthofuran is a metabolite of pulegone. Both in vitro and in vivo studies have found the pulegone metabolite menthofuran to be an inhibitor of CYP2A6. Menthofuran may deplete glutathione levels, leaving hepatocytes vulnerable to free radical damage.


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